Gather all ingredients.

Preheat the oven to 375 degrees F (190 degrees C). Line a 10x15-inch baking pan with a wire rack.

Trim silver skin and excess fat from the pork tenderloin.

Combine brown sugar, salt, Chinese five spice powder, garlic powder, onion powder, and black pepper in a small bowl.

Sprinkle tenderloin all over with the spice mixture, rubbing to coat.

Heat oil in a 12-inch skillet over medium-high heat. Sear tenderloin until browned on all sides, 8 to 10 minutes.

Place tenderloin on the rack in the prepared pan. Bake in the preheated oven until an instant-read thermometer inserted near the center reads 140 degrees F (61 degrees C), about 20 to 25 minutes.

Remove from oven, tent with foil, and let rest for 10 minutes. Internal temperature will rise to 145 degrees F (63 degrees C) or higher.

Meanwhile for sauce, heat honey, soy sauce, vinegar, and garlic in the same skillet. Simmer until liquid reduces and thickens, about 5 minutes.