Mix flour, salt, pepper, and garlic powder together in a 1-gallon resealable bag. Add chicken wings, seal bag, and turn evenly to coat chicken.

Heat oil in a deep-fryer or large saucepan to 375°F (190°C).

Remove wings from bag and shake off any excess coating. Fry wings, in batches if necessary, until no longer pink in the center, about 7 minutes.

Remove wings with a slotted spoon and drain on a paper towel-lined plate.

Combine hot sauce and butter in a saucepan over medium heat. Cook until heated through, about 5 minutes.